IDENTIFICATION OF PROTEIN COMPLEXES AND PHOSPHORYLATION SITES OF PROTEINS REQUI

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。McCollum实验室研究了分裂酵母S. pombe中的一个信号通路，称为分裂起始网络（SIN），它在有丝分裂结束时起作用，触发细胞质分裂的起始。SIN的组成部分定位到主轴杆体（SPB）。Sid2p激酶和Mob1p形成复合物，在通路末端发挥作用，将SPB的信号传递到细胞分裂位点，从而触发细胞质分裂的起始。研究Sid2p和Mob1p的调控。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The McCollum lab studies a signaling pathway in the fission yeast S. pombe, termed the septation initiation network (SIN), which functions at the end of mitosis to trigger initiation of cytokinesis. The components of the SIN localize to the spindle pole body (SPB). The Sid2p kinase and Mob1p form a complex and function at the end of the pathway to transmit a signal from the SPB to the cell division site to trigger initiation of cytokinesis. We will study the regulation of Sid2p and Mob1p.