DYNAMICS OF THE CONTRACTILE RING FILAMENT NETWORK DURING CYTOKINESIS

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。胞质分裂完成细胞分裂，确保产生两个含有单一基因组互补的子细胞。在动物细胞中，胞质分裂需要在分裂后期围绕细胞赤道组装的皮质收缩环的收缩。环的结构成分包括三种蛋白质聚合物系统：肌动蛋白、肌球蛋白II和septins。收缩环的组织和收缩机制仍然知之甚少。我建议使用C。elegans胚胎作为模型系统，分析了三种聚合物系统在环收缩过程中的分布、动力学性质和功能相互作用。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Cytokinesis completes cell division, ensuring the generation of two daughter cells that contain a single genomic complement. In animal cells, cytokinesis requires the constriction of a cortical contractile ring that assembles around the cell equator during anaphase. The structural components of the ring include three protein polymer systems: actin, myosin II, and the septins. The organization and mechanism of constriction of the contractile ring remain poorly understood. I propose to use the C. elegans embryo as a model system to analyze the distribution, dynamic properties and functional interactions between the three polymer systems during ring constriction.