EXPERIENCE-DEPENDENT PREFRONTAL WHITE MATTER GROWTH AND DEVELOPMENT IN MONKEYS

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。情绪和认知发展的神经生物学研究很少考虑白质，尽管有迹象表明这些过程依赖于复杂的神经网络和白质的相互联系。人类和非人类灵长类动物的前额叶白质体积在整个童年和青春期通过磁共振成像测定。前额叶白质生长和发育的其他证据来自于从水质子扩散推断的组织微观结构的扩散张量成像（DTI）测量。在整个青少年时期，由于神经纤维束的髓鞘形成，前额叶白质的扩散方向越来越受到限制。为了证实猴子在青春期也会发生类似的变化，我们最初使用单次回波平面成像（EPI）协议收集DTI数据，该协议产生几何扭曲和敏感性伪影。随后使用扩散加权自旋回波线扫描成像（LSDI）获得8厘米视场的数据。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Neurobiological studies of emotional and cognitive development seldom consider white matter despite indications that these processes depend on complex neural networks and white matter interconnections. Prefrontal white matter volumes in human and nonhuman primates determined in vivo by magnetic resonance imaging increase throughout childhood and adolescence. Additional evidence for prefrontal white matter growth and development comes from diffusion tensor imaging (DTI) measures of tissue microstructure inferred from water proton diffusion. The direction of diffusion in prefrontal white matter is increasingly restricted throughout adolescence in humans by ongoing myelination of nerve fiber tracts. To confirm that similar changes occur during adolescence in monkeys, we initially collected DTI data with a single-shot echo-planar imaging (EPI) protocol that produced geometric distortions and susceptibility artifacts. Diffusion-weighted spin echo line scan imaging (LSDI) was subsequently used to acquire data at 8 cm field of view.