SOLUTION STRUCTURE OF SERINE-RICH DOMAIN FROM CRK-ASSOCIATED SUBSTRATE

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。130cas （crk相关底物）是一种对接蛋白，参与局灶黏附的组装和伴随的细胞信号传导。它在细胞粘附、迁移、存活和增殖的生理调控中发挥作用，并在致瘤转化中发挥作用。该分子由多个蛋白-蛋白相互作用基序组成，包括位于Crk和src结合位点之间的富含丝氨酸的区域。本研究报道了Cas的第一个功能域结构。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. 130cas (Crk-associated substrate) is a docking protein that is involved in assembly of focal adhesions and concomitant cellular signaling. It plays a role in physiological regulation of cell adhesion, migration, survival, and proliferation, as well as in oncogenic transformation. The molecule consists of multiple protein-protein interaction motifs, including a serine-rich region that is positioned between Crk and Src-binding sites. This study reports the first structure of a functional domain of Cas.