Systems Engineering of Pheresis Intervention for Sepsis

为了回应：PAR-04-023，我们提议建立生物工程研究伙伴关系，以设计和测试 基于血液吸附原理的严重脓毒症体外治疗装置。我们的多- 学科团队包括基础科学和临床研究人员、生物工程和生物材料专家，以及 复杂系统建模方面的专家。我们的提案将仔细地整合来自 技术和生物医学领域，跨越多个科学学科的边界，利用 产业界和学术界的能力。我们的项目名为《疾病干预的系统工程》 用于脓毒症(败血症)。 严重脓毒症(感染时的急性起病器官衰竭)是一个主要的健康问题，几乎导致死亡。 每年25万美国人，花费数十亿美元。脓毒症的可用治疗方法，包括最近的那些 被批准的，是次优的，迫切需要新的治疗方法。然而，炎症的复杂性 反应网络和临床试验的高昂成本，特别是在危重病人中，使传统的 药物/设备开发模式已过时。我们之前已经开发并测试了体外血液 用于治疗慢性肾脏疾病的净化装置，并已将该装置用于治疗急性肾功能衰竭 炎症性疾病。我们还开发并部分校准了啮齿动物和人类的 脓毒症的数学模型。该项目建议将这两项成果结合起来，并通过 迭代设计过程，开发一种可用于治疗严重脓毒症的装置。 这项建议的目标是设计一种用于治疗慢性阻塞性肺疾病的体外血液净化装置 严重的败血症。这项提案将汇集来自加州大学下列部门的调查人员 匹兹堡：生物工程、化学工程、重症监护医学、外科、医学和数学。 我们还将邀请两家公司的专业知识，其中一家专门从事吸附聚合物技术(MedaSorb 技术，有限责任公司)和复杂系统建模(免疫公司)。

In response to: PAR-04-023, we are proposing a Bioengineering Research Partnership to design and test an extracorporeal device for the treatment of severe sepsis, based on the principle of hemoadsorption. Our multi- disciplinary team comprises basic science and clinical researchers, bioengineering and biomaterials experts, and experts in complex systems modeling. Our proposal will carefully integrate this diverse group of researchers from both technical and biomedical fields, crossing the boundaries of multiple scientific disciplines and leveraging the capabilities of both industry and academia. Our project is entitled Systems Engineering of a Pheresis Intervention for Sepsis (SEPsIS). Severe sepsis (acute onset organ failure in the setting of infection) is a major health problem that kills nearly 250,000 Americans each year and costs billions of dollars. Available therapies for sepsis, including those recently approved, are suboptimal and new therapies are urgently needed. However, the complexities of the inflammatory response network and the high cost of clinical trials, particularly in the critically ill, renders the traditional drug/device development paradigm obsolete. We have previously developed and tested an extracorporeal blood purification device for treatment in chronic renal disease and have adapted this device for the treatment of acute inflammatory diseases. We have also developed and partially calibratedin both rodents and humansa mathematical model of sepsis. This project proposes to integrate these two achievements and, through an iterative design process, develop a device that can be used to treat severe sepsis. The goal of this proposal is to design an extracorporeal blood purification device for the treatment of severe sepsis. This proposal will bring together investigators from the following departments at the University of Pittsburgh: Bioengineering, Chemical Engineering, Critical Care Medicine, Surgery, Medicine, and Mathematics. We will also call on the expertise of two companies, one specializing in adsorbent polymer technology (MedaSorb Technologies, LLC) and the other in complex systems modeling (Immunetrics, Inc.).