PROSTATE, LUNG, COLORECTAL AND OVARIAN (PLCO) CANCER SCREENING TRIAL

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。将检验以下假设：a)通过直肠指检和PSA血液测试筛查前列腺癌将降低前列腺癌的死亡率；b)通过胸部X光筛查肺癌将降低肺癌的死亡率；c)乙状结肠镜筛查结直肠癌将减少结肠癌/直肠癌；d)经阴道超声和CA-125筛查卵巢癌将降低卵巢癌的死亡率。所有受试者的年龄都在55-74岁之间。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The following hypotheses will be tested: a) screening for prostate cancer with digital rectal exam and PSA blood test will reduce the mortality from prostate cancer; b) screening for lung cancer with chest x-ray will reduce mortality from lung cancer; c) screening for colorectal cancer with sigmoidoscopy will reduce colon/rectal cancer, and d) screening for ovarian cancer with transvaginal ultrasound and CA-125 will reduce mortality from ovarian cancer. All subjects will be age 55 - 74.