ASSESSING THE PREVALENCE OF THE BK, CMV, & ADENOVIRUS INFECTIONS IN PED PTS

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。这项试验的目的是评估BK、CMV和腺病毒在接受造血干细胞移植的儿童患者中的流行率。我们将对接受造血干细胞移植(HSCT)的儿童患者的尿液和血液中BK、CMV和腺病毒的存在和水平进行经度分析。我们期望BK、CMV和腺病毒水平与以下因素相关：1)基础疾病(恶性与遗传性)，2)既往药物治疗，3)移植类型(兄弟姐妹、无关供者、脐带血、单倍体相合)，4)出血性膀胱炎或其他可能的BK、CMV或腺病毒相关疾病，5)同时进行抗病毒治疗，6)免疫功能恢复，以及7)免疫抑制强度。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this trial is to assess the prevalence of the BK, CMV, and adenovirus in pediatric patients undergoing hematopoietic stem cell transplantation. We will perform longitude analysis of the presence and levels of BK, CMV, and adenovirus in the urine and blood of pediatric patients undergoing hematopoietic stem cell transplant (HSCT). We expect to correlate levels of BK, CMV, and adenovirus with the following: 1) underlying disease (malignant vs. genetic), 2) prior medications, 3) transplant type (sibling, unrelated donor, cord blood, haploidentical), 4) hemorrhagic cystitis or other possible BK, CMV, or adenovirus virus-related disease, 5) inter-current anti-viral therapy, 6) immune function recovery, and 7) immune suppression intensity.