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Autophagy as a component of the innate immune response

Autophagy as a component of the innate immune response
自噬作为先天免疫反应的一个组成部分
批准号：
7689597
负责人：
MICHELE Somes SWANSON
金额：
$37.77万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
项目状态：
已结题
起止时间：
2008-09-22 至 2010-08-31
来源：
https://reporter.nih.gov/project-details/7689597
关键词：
Alveolar MacrophagesAmino AcidsAutophagocytosisAutophagosomeBacteriaBiological AssayC57BL/6 MouseCaspase-1Cell DeathCommitComplexCytolysisCytoplasmDataDevelopmentDoseEnzyme-Linked Immunosorbent AssayEpitopesFlagellinFluorescence MicroscopyGeneticHumanImmune responseImmune systemInfectionInflammatoryInterleukin-18KnowledgeLegionella pneumophilaLeukocytesLifeLungLysosomesMammalian CellMicrobeMicroscopyMolecularMusNatural ImmunityNutrientPathway interactionsPatternProteinsRateRouteSignal TransductionStarvationTestingToll-like receptorsVirulenceVirulentWithdrawalabstractingdeprivationmacrophagemicrobialmutantparticlepathogenrespiratoryresponsetooltrait

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中文摘要
翻译
摘要 先天免疫领域的一个令人兴奋的发展是发现巨噬细胞 利用自噬来保护它们的细胞质不受感染。营养匮乏由来已久 已知可诱导自噬，但感染是如何迅速触发这一替代途径的 消化溶酶体知之甚少。遗传数据表明，小鼠对L. 依赖NOD样蛋白检测胞液鞭毛和 然后通过自噬来消化微生物，或者进行促炎细胞死亡 被称为上睑下垂。为了确定巨噬细胞如何整合自噬和 嗜肺军团菌作为微生物感染的屏障，我们将利用军团菌作为 先天免疫系统的遗传探针。
英文摘要
Abstract An exciting development in the innate immunity field is the discovery that macrophages enlist autophagy to protect their cytoplasm from infection. Nutrient deprivation has long been known to induce autophagy, but how infection rapidly triggers this alternate route to digestive lysosomes is poorly understood. Genetic data indicate that mice resist L. pneumophila infection by relying on NOD-like proteins to detect cytosolic flagellin and then to digest the microbes by autophagy or to commit a pro-inflammatory cell death known as pyroptosis. To determine how macrophages integrate autophagy and pyroptosis as barriers to microbial infection, we will exploit Legionella pneumophila as a genetic probe of the innate immune system.
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会议论文
2014 Microbial Toxins and Pathogenicity Gordon Research Conference & Gordon Resea
  • 批准号：
    8782883
  • 项目类别：
  • 资助金额：
    $0.8万
  • 财政年份：
    2014
  • 负责人：
    MICHELE Somes SWANSON
  • 依托单位：
    GORDON RESEARCH CONFERENCES
Analysis of L. Pneumophilia Virulence Regulation
FASEB Summer Research Conference "Microbial Pathogenesis: Mechanisms of Infectio
Autophagy as a component of the innate immune response
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