MEAL-RELATED CHANGES IN GUT HORMONES IN LEAN AND OBESE CHILDREN

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。肥胖已经成为一种流行病，全世界有超过10亿人受到影响。在美国，现在有超过30%的儿童超重或肥胖，这导致了儿科人群中高血压、高脂血症和2型糖尿病的发病率增加。在过去的十年里，关于食欲和体重的神经内分泌控制，特别是脂肪组织和大脑之间的信号传导途径，已经有了很多研究。最近的研究表明，肠道分泌的激素，如胃饥饿素和肽YY (PYY)，通过向下丘脑提供关于饥饿和饱腹感的信号，在能量平衡中发挥重要作用。这些研究大多是在成人中进行的，只有有限的关于儿童的信息。关于其他肠道激素在儿童食欲调节中的作用，如胰腺多肽（PP）、胆囊细胞激肽（CCK）和胰高血糖素样肽1 (GLP-1)，我们所知的就更少了。因此，我们建议在一组瘦弱和肥胖儿童中评估这些激素水平，以提高我们对食欲和能量平衡是如何调节的理解。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Obesity has become a pandemic, with more than 1 billion people affected worldwide. More than 30% of children in the United States are now overweight or obese, which has led to an increase in the incidence of hypertension, hyperlipidemia, and type 2 diabetes in the pediatric population. In the last decade, much has been learned about the neuroendocrine control of appetite and weight, especially the signaling pathways between adipose tissue and the brain. More recently, studies have shown that hormones secreted by the intestine, such as ghrelin and peptide YY (PYY), have important roles in energy balance by providing signals to the hypothalamus about hunger and satiety. Most of these studies have been done in adults, with only limited information available in children. Even less is known about the roles of other intestinal hormones in appetite regulation in children, such as pancreatic polypeptide (PP), cholecytokinin (CCK), and glucagon-like peptide 1 (GLP-1). We therefore propose to evaluate these hormone levels in a group of lean and obese children in order to improve our understanding of how appetite and energy balance are regulated.