LINKING DEPRESSION WITH INCREASED MORBIDITY AND MORTALITY IN PATIENTS W HF

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。本研究的目的是探讨这两个潜在的机制，抑郁症和心力衰竭（HF）的发病率和死亡率增加之间的已知关联。本研究的具体目的是确定交感神经系统（SNS）唤醒和不依从是否有助于抑郁症和心力衰竭结局较差之间的相关性。这一目标将在一项前瞻性相关性研究中进行测试，其中将测试DND唤醒和不依从对抑郁症与HF患者结局之间关联的介导作用。将对共计300例确诊为缺血性病因所致慢性HF伴左心室收缩功能受损的患者进行随访。这项研究的结果将提供有关抑郁症和不良结局之间联系的机制的重要信息，临床医生和研究人员可以在设计有效的干预措施时使用

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to explore these two potential mechanisms for the known association between depression and increased morbidity and mortality in Heart Failure (HF). The specfic aim for this study is to determine whether both Sympathetic nervous system (SNS) arousal and nonadherence contribute to the association between depression and poorer HF outcomes. This aim will be tested in a prospective correlational study in which the mediating effects of both DND arousal and nonadherence on the association between depression and the HF patient outcomes will be tested. A total of 300 patients with a confirmed diagnosis of chronic HF from an ischemic etiology with impaired left ventricular systolic function will be followed. Results of this study will provided vital information about the mechanisms linking depression and poor outcomes that clinicians and researchers can use in the design of effective intervention