GESTATIONAL DIABETES MELLITUS: IMPACT ON ORAL HEALTH

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。一般的假设是，患有妊娠期糖尿病的妇女比非妊娠期糖尿病的妇女患更严重的牙周病的风险更高，而且妊娠期糖尿病和牙周病的结合将与对母婴健康的负面影响增加相关。以下是为解决这个问题而设计的具体目标。研究妊娠期糖尿病患者与非妊娠期糖尿病患者牙周炎的患病率、程度和严重程度，以及牙周炎与不良母婴结局之间的关系。目的2将描述妊娠期糖尿病和牙周病患者的牙龈下微生物生态，并确定特定微生物特征是否与不良妊娠和胎儿结局有关。目的3将确定GDM和牙周炎患者的循环炎症介质水平是否高于GDM和无牙周炎的女性和非GDM对照组。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. General hypothesis is that women with GDM are at higher risk for developing more severe periodontal disease than women without GDM and that the combination of GDM and periodontal disease will be associated with an increased negative impact on maternal and fetal health. The following Specific Aims are designed to address this question. To Characterize the prevalence, extent and severity of of periodonitis and associations between periodontits and adverse maternal and fetal outcomes in women who develop GDM compared to women who don't develop GDM. Aim 2 will characterize the subgingival microbial ecology in women with GDM and periodontal disease and determine if specific microbial characteristics are associated with adverse pregnancy and fetal outcomes. Aim 3 will determine if patients with GDM and periodontitis have elevated levels of circulating inflammatory mediators comaper to women with GDM and no periodonititis and the non-GDM controls.