CLINICAL TRIAL OF IMMUNOTHERAPY WITH A CANDIDATE EXTRACT OF NON-AMMONIATED LATEX

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。这项研究的主要原因是为了确定乳胶过敏患者注射乳胶过敏的一般安全性和有效性。对于那些过敏的人来说，完全避免乳胶暴露是目前唯一的治疗方法，如果不改变职业，这通常是不可能实现的，这对经济造成影响，有时对卫生保健专业人员和其他人来说是不可接受的。此外，一些研究表明，转移到乳胶接触最少的新环境可能不足以避免持续的症状或帮助治疗慢性呼吸道疾病。因此，需要额外的选择是非常重要的。有理由相信，与传统过敏注射类似的定期乳胶过敏注射治疗可能在减少乳胶过敏方面取得成功。我们计划在这项研究中招募六名受试者，三名过敏性哮喘患者和三名没有哮喘的过敏性受试者。在这项试验中，我们将通过收集几种检测方法的证据，监测乳胶注射对受试者免疫系统的影响。反复验血的结果、皮肤测试以及呼吸空气中乳胶微粒的挑战将是我们将使用的终点。这项研究的结果将告诉我们，对于医护人员和乳胶过敏患者来说，这是否是一种实用和安全的可能治疗形式。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The primary reason for this study is to determine the general safety and effectiveness of latex allergy injections in latex allergic individuals. Complete avoidance of latex exposure is the only current remedy for those that are allergic and this is often impossible to achieve without an occupational change, which is economically impacting as well as sometimes unacceptable to health care professionals and others. Furthermore, some studies suggest that moving to a new environment where latex exposure is minimal may not be enough to avoid continuing symptoms or to help with chronic respiratory disease. The need for additional options is therefore very important. There is reason to believe that treatment with regular latex allergy injections similar to traditional allergy injections may be successful in reducing latex allergy. We plan to enroll six subjects in this study, three allergic asthmatics and three allergic subjects who do not have asthma. During this trial, we will monitor the effects of the latex injections on the immune systems of the subjects, by gathering evidence from several testing methods. Results from repeated blood work; skin testing and challenges of breathing airborne latex particles will be the endpoints we will be using. The results of this study will tell us if this is a practical and safe form of possible treatment for healthcare workers and patients with latex allergy.