LUNG CHANGES IN YOUNG ADULTS WITH MODERATE TO SEVERE ASTHMA-HRCT SCANS, METHACHS

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。儿童哮喘研究(CAS)是一项广谱过敏原免疫治疗的随机、掩蔽、安慰剂对照试验，确定了一组患有中到重度哮喘的年轻人，他们现在有持续性的肺功能缺陷。为了进一步确定这些功能缺陷的性质，这些研究人员提出了一个三部分的研究，以检查这些受试者的肺解剖和病理生理学，包括高分辨率呼吸道CT扫描(HRCT)、乙酰甲胆碱激发试验、诱导痰(IS)和呼出冷凝物研究(EBC)。这些研究人员假设，持续性肺功能缺陷的受试者将与其他队列成员区分开来，证据包括CT扫描上气道增厚和扩张性降低，乙酰甲胆碱敏感性表现的气道高反应性增加，以及IS和EBC采样中炎性标志物的增加。这些研究对儿童哮喘的监测和预后有重要意义。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Childhood Asthma Study (CAS), a randomized, masked, placebo controlled trial of broad spectrum allergen immunotherapy, identified a group of young adults with moderate to severe asthma who now have persistent lung function deficits. In order to characterize the nature of these functional deficits further, these investigators propose a three part study to examine the lung anatomy and pathophysiology in these subjects including high resolution CT scanning of the airways (HRCT), methacholine challenge tests, and induced sputum (IS) and exhaled condensate studies (EBC). These investigators hypothesize that subjects with persistent lung function deficits will be distinguishable from other cohort member by evidence of increased airway thickening and reduced distensibility on CT scans, increased airway hyperreactivity as expressed by methacholine sensitivity, and increased inflammatory markers on IS and EBC sampling. These studies have important implications for monitoring and prognosis of childhood asthma.