CHEMOTHERAPY INTENSIFICATION THROUGH INTERVAL COMPRESSION IN EWING'S SARCOMA

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。这项研究不再招募病人。(来自国家癌症研究所的PDQ数据库的临床试验摘要)化疗中使用的药物以不同的方式阻止肿瘤细胞分裂，从而停止生长或死亡。放射疗法使用高能X射线来破坏肿瘤细胞。目前尚不清楚哪种化疗方案结合放射治疗和/或手术治疗尤文肉瘤或原始神经外胚层肿瘤更有效。这是一项随机的III期试验，旨在比较不同化疗方案结合放射治疗和/或手术治疗尤文氏肉瘤或原始神经外胚层肿瘤患者的疗效。患者将随机分配到两组中的一组。第1组患者接受联合化疗，每3周2-5天，最多4个疗程。第2组接受联合化疗，每2周1次，每次2~5天，共6个疗程。从第13周开始，两组中的一些患者都将接受手术切除肿瘤，然后进行化疗，并进行或不进行放射治疗。其他患者要么在手术前接受放射治疗，然后再接受额外的放射治疗加化疗，要么单独接受放射治疗加化疗。患者将在4年中每3个月评估一次，在1年中每6个月评估一次。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study is no longer recruiting patients. (Clinical trial summary from the National Cancer Institute's PDQ database) Drugs used in chemotherapy work in different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells. It is not yet known which chemotherapy regimen combined with radiation therapy and/or surgery is more effective in treating Ewing's sarcoma or primitive neuroectodermal tumor. This is a randomized Phase III trial to compare the effectiveness of different chemotherapy regimens combined with radiation therapy and/or surgery in treating patients who have Ewing's sarcoma or primitive neuroectodermal tumor. Patients will be randomly assigned to one of two groups. Patients in Group 1 will receive infusions of combination chemotherapy on 2-5 days every 3 weeks for up to four courses. Patients in Group 2 will receive infusions of combination chemotherapy on 2-5 days every 2 weeks for up to six courses. Beginning in Week 13, some patients in both groups will undergo surgery to remove the tumor followed by chemotherapy with or without radiation therapy. Other patients will either undergo radiation therapy before surgery followed by additional radiation therapy plus chemotherapy or undergo radiation therapy alone plus chemotherapy. Patients will be evaluated every 3 months for 4 years and every 6 months for 1 year.