METABOLIC EFFECTS OF GROWTH HORMONE UPON BODY COMPOSITION IN TODDLERS WITH PWS

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。Prader-Willi综合征(PWS)是一种罕见的与肥胖相关的遗传性疾病。在生命早期，患有PWS的儿童体重增加较少，肌肉张力较低。这项研究评估了生长激素(GH)对这些情况的影响。这项随机对照研究将对接受生长激素治疗的PWS儿童和对照PWS儿童进行比较。结果将包括测量身体脂肪、肌肉质量、能量消耗、激素水平和

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Prader-Willi syndrome (PWS) is a rare genetic disorder associated with obesity. Early in life, children with PWS demonstrate poor weight gain and low muscle tone. This study evaluates the effect of growth hormone (GH) upon these conditions. This randomized controlled study will compare children with PWS treated with GH compared to control PWS children. Outcomes will include measuring body fat, muscle mass, energy expenditure, hormonal levels an