PACTG P1025 PHARMACOKINETIC PROPERTIES OF ANTIRETROVIRAL DRUGS DURING PREGNANCY

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。评估为预防艾滋病毒垂直传播和/或妇女健康而规定的干预措施的有效性。评估为妇女健康和/或预防艾滋病毒垂直传播开出的干预措施的母婴安全性。为密集的分研究提供框架和标本库，旨在进一步阐明艾滋病毒垂直传播的风险因素和机制，以及影响母婴结局的因素。评估感染艾滋病毒的孕妇在孕期和产后对抗逆转录病毒疗法的依从性及其对妇女健康和垂直传播的影响，并评估婴儿对化学预防的依从性。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Assess the effectiveness of interventions prescribed for prevention of vertical transmission of HIV and/or for women's health. Assess maternal and infant safety of interventions prescribed for women's health and/or prevention of vertical transmission of HIV. Provide framework and specimen repository for intensive substudies that aim to further elucidate risk factors for and mechanisms of vertical transmission of HIV as well as factors that affect maternal and infant outcomes. Assess adherence to ART among HIV-infected pregnant women during pregnancy and postpartum and its impact on women's health and vertical transmission and to assess adherence to chemoprophylaxis in infants.