ROLE OF DOPAMINE METABOLISM IN ANTIDEPRESSANT EFFECT OF SLEEP DEPRIVATION

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。确定是否可以通过使用药物、改变就寝时间和光线治疗来延长睡眠剥夺的抗抑郁效果。对于许多患者来说，彻夜不眠可以立即改善他们第二天的抑郁。问题是，一旦这个人第二天晚上再次入睡，他们就会再次变得抑郁。没有其他治疗抑郁症的方法有如此立竿见影的效果。研究人员将进行测试，看看是否可以通过增加两种额外的治疗方法来延长睡眠剥夺的有益效果，即在接下来的两个晚上提前就寝时间和暴露在强光下。这将与使用抗抑郁药物舍曲林和稳定情绪药物锂的通常治疗形式进行比较，看看它们是否更好。PET将用于研究大脑的活动和大脑化学物质或神经递质多巴胺的作用。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Determine if the antidepressant effect of sleep deprivation can be made to last longer through the use of medications, change in bedtime and treatment with light. For many patients staying up all night without sleep can immediately improve their depression the next day. The problem is that once the person goes to sleep again the next night, they become depressed again. No other treatment for depression has such an immediate effect. Investigators will test to see if the beneficial effect of sleep deprivation can be extended by adding two additional treatments, an earlier bedtime on the two following nights and exposure to bright light. This will be compared to the usual form of treatment using the antidepressant medication, sertraline, and the mood stabilizing medication, lithium, to see if they are better. PET will be used to study the activity of the brain and the role of a brain chemical or neurotransmitter dopamine.