STUDY TO DETERMINE THE SITE OF INTESTINAL CYSTEAMINE ABSORPTION

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心机构，不一定为研究者机构。测定直接给药至胃、小肠或结肠时半胱胺对白细胞胱氨酸、血液半胱胺和胃泌素水平的影响。了解高胃泌素血症和胃酸分泌过多是否因半胱胺输送部位而异。决定开发一种缓释半胱胺递送系统是否有利，或者简单地将药物递送到不同的肠道部位是否有显著的优势。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Determine the effect of cysteamine on leukocyte cystine, blood cysteamine and gastrin levels when administered directly into the stomach, small intestine or colon. Learn if hypergastrinemia and gastric acid-hypersecretion differ based on the site of cysteamine delivery. Decide whether it might be advantageous to develop a slow-release cysteamine delivery system or whether there would be a significant advantage to simply delivering the drug to a different intestinal site.