HCV VIRAL DECAY DURING THERAPY IN THOSE CO-INFECTED WITH HCV AND HIV

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。这项初步研究的目的是：1)前瞻性地评价HIV/丙型肝炎病毒混合感染者与丙型肝炎病毒单一感染者在早期病毒动力学参数和病毒学应答率上的差异；2)评价HIV/丙型肝炎病毒感染者在治疗前和治疗期间与丙型肝炎病毒单一感染者相比的丙型肝炎病毒准物种多样性的差异；3)评估外周血淋巴细胞中丙型肝炎病毒复制的位置；4)评价HIV/丙型肝炎病毒感染者与丙型肝炎病毒单一感染者相比的丙型肝炎病毒相关免疫反应。这项研究的假设是，艾滋病毒和丙型肝炎病毒之间的相互作用可能会损害艾滋病毒/丙型肝炎患者对丙型肝炎病毒治疗的宿主反应。该项目是为K23提交文件做准备的试验性研究。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The aims of this pilot study are: 1) to prospectively evaluate the differences in early viral kinetic parameters and virologic response rates in HIV/HCV co-infected subjects compared to HCV mono-infected subjects 2) to evaluated differences in HCV quasi-species diversity in HIV/HCV co-infected subjects before and during treatment in comparison to HCV mono-infected subjects 3) to evaluate peripheral blood lymphocytes for extrahepatic site of HCV replication 4) to evaluate the HCV related immune response in HIV/HCV compared to HCV mono-infection. The hypothesis of the study is that interaction between the HIV and HCV may impair the host response to HCV therapy in HIV/HCV subjects. This project is a pilot study in preparation for a K23 submission