ANABOLIC THERAPIES FOR MUSCLE DYSFUNCTION IN WOMEN WITH COPD

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。为了确定是否通过1)补充睾酮或2)力量训练可以改善患有严重慢性阻塞性肺病的女性的运动耐受性。为患有肺病、支气管炎和肺气肿的妇女设计更好的康复方法。该项目是在对患有这些疾病的男性进行类似治疗的研究之后进行的。将探索两种治疗方法：1)睾丸激素，已知可以增强肌肉；2)腿部肌肉的力量训练（例如举重）。人们正在探索前一种疗法，因为越来越清楚的是，尽管女性的睾丸激素水平比男性低得多，但睾丸激素是女性肌肉生长的重要媒介。患有肺部疾病的女性睾酮水平较低，我们的目的是将睾酮水平提高到健康年轻女性的水平。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. To determine whether the exercise tolerance of women with severe COPD will be improved by 1) testosterone supplementation or 2) strength training. To devise better ways to rehabilitate women with lung diseases, bronchitis and emphysema. This project follows on a study of similar therapies in men with these diseases. Two therapies will be explored: 1) testosterone, known to strengthen the muscles, 2) strength training (for example, weight lifting) of the leg muscles. The former therapy is being explored because it is becoming clear that although levels of testosterone are much lower in women than in men, testosterone is an important mediator of muscle growth in women. Testosterone levels have been found to be low in women with lung disease and our intention is to increase levels to those seen in healthy young women.