ASSESSMENT OF INTERACTION OF COCAINE AND QUETIAPINE (SEROQUEL)

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。研究目的：这是一项人体实验室临床药理学研究，旨在评估服用3种剂量奎硫平的受试者静脉注射可卡因的安全性。目的是提供初步的主观性、安全性和耐受性数据，以便决定是否应该进行奎硫平治疗可卡因依赖的临床试验。主要目的：主要目的是通过测量主观、实验室和生理反应来确定奎硫平与静脉注射20毫克和40毫克可卡因之间是否存在显著的相互作用。第二部分：1.评价奎硫平给药是否改变可卡因或其主要代谢物苯甲酰ecGonine(BE)的药代动力学。2.评估奎硫平治疗是否改变了可卡因对欲望的影响，这是通过评估滥用倾向的主观评分表来衡量的，目的是确定是否存在可卡因依赖潜在疗效的信号。3.用标准评定量表评价奎硫平对情绪和人格的影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Study Objectives: This is a human laboratory clinical pharmacology study to assess the safety of intravenous cocaine in subjects taking quetiapine at 3 dosage levels. The purpose is to provide preliminary subjective, safety, and tolerability data to inform a decision on whether clinical trials of quetiapine in cocaine dependence should be conducted. Primary: the primary objective is to determine whether there are significant interactions between quetiapine administered concurrently with IV cocaine infusions of 20 mg and 40 mg by measuring subjective, laboratory, and physiologic responses. Secondary: 1. To evaluate whether the administration of quetiapine alters the pharmacokinetics of cocaine or its major metabolite, benzoylecgonine (BE). 2. To evaluate whether treatment with quetiapine alters the effects of cocaine on craving, as measured by subjective rating scales that assess abuse liability, for the purpose of determining whether there is a signal for potential efficacy in cocaine dependence. 3. To assess the effect of quetiapine on mood and personality using standard assessment scales.