ASSESSMENT OF IV COCAINE USING PHARMACOKINETIC/PHARMACODYNAMIC EFFECT
ASSESSMENT OF IV COCAINE USING PHARMACOKINETIC/PHARMACODYNAMIC EFFECT
批准号:
6264091
负责人:
DOMENIC A CIRAULO
金额:
$4.27万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1998
资助国家:
美国
项目状态:
已结题
起止时间:
1998-12-01 至 1999-11-30
关键词:
behavioral /social science research tag brain electrical activity cardiovascular function clinical research clinical trial phase I cocaine disease /disorder model dosage electroencephalography human subject intravenous drug abuse nicotine pharmacokinetics psychological models psychophysiology substance abuse related behavior
中文摘要
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英文摘要
This study is designed to investigate the pharmacokinetic/pharmacodynamic models of the physioloigical and psychological effects of intravenous administration of cocaine. The pharmacodynamic effects of interest include cardiovascular, subjective, and electroencephalographic effects. This will be a single blind inpatient study in which saline and 20mg and 40mg doses of cocaine will be administered intravenously in a pseudo-random fashion. Six healthy subjects with a history of recent cocaine abuse, who meet criteria for cocaine abuse or dependence but are currently not dependent on any other substance except nicotine will be studied in this investigation.
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会议论文
Interdisciplinary Study of Two Novel Anticonvulants in Alcoholism
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批准号:7759646
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项目类别:
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资助金额:$55.11万
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财政年份:2009
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负责人:DOMENIC A CIRAULO
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依托单位:
Interdisciplinary Study of Two Novel Anticonvulants in Alcoholism
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批准号:8401165
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项目类别:
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资助金额:$42.06万
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财政年份:2009
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负责人:DOMENIC A CIRAULO
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依托单位:
Interdisciplinary Study of Two Novel Anticonvulants in Alcoholism
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批准号:8208221
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项目类别:
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资助金额:$53.92万
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财政年份:2009
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负责人:DOMENIC A CIRAULO
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依托单位:
Interdisciplinary Study of Two Novel Anticonvulants in Alcoholism
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批准号:8018617
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项目类别:
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资助金额:$54.37万
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财政年份:2009
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负责人:DOMENIC A CIRAULO
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依托单位:
Interdisciplinary Study of Two Novel Anticonvulants in Alcoholism
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批准号:7583311
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项目类别:
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资助金额:$55.47万
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财政年份:2009
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负责人:DOMENIC A CIRAULO
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依托单位:
ASSESSMENT OF INTERACTION OF COCAINE AND QUETIAPINE (SEROQUEL)
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批准号:7379484
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项目类别:
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资助金额:$6.41万
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财政年份:2005
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负责人:DOMENIC A CIRAULO
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依托单位:
ASSESSMENT OF INTERACTION OF COCAINE AND QUETIAPINE
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批准号:7206282
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项目类别:
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资助金额:$2.32万
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财政年份:2004
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负责人:DOMENIC A CIRAULO
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依托单位:
NEUROIMAGING COLLABORATIVE STUDY/TIAGABINE
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批准号:7206273
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项目类别:
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资助金额:$0.85万
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财政年份:2004
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负责人:DOMENIC A CIRAULO
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依托单位:
Cognitive-Behavioral Therapy & Venlafaxine Treatments For Anxiety In Alcoholism
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批准号:7268910
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项目类别:
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资助金额:$34.43万
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财政年份:2003
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负责人:DOMENIC A CIRAULO
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依托单位:
Neuroimaging Collaborative Study/Tiagabine
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批准号:7042199
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项目类别:
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资助金额:$0.43万
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财政年份:2003
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负责人:DOMENIC A CIRAULO
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依托单位:
CBT And Venlafaxine Treatments For Anxiety In Alcoholism
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批准号:6806477
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项目类别:
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资助金额:$49.54万
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财政年份:2003
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负责人:DOMENIC A CIRAULO
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依托单位:
CBT And Venlafaxine Treatments For Anxiety In Alcoholism
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批准号:6929931
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项目类别:
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资助金额:$52.04万
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财政年份:2003
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负责人:DOMENIC A CIRAULO
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依托单位:
CBT And Venlafaxine Treatments For Anxiety In Alcoholism
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批准号:6682159
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项目类别:
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资助金额:$43.79万
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财政年份:2003
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负责人:DOMENIC A CIRAULO
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依托单位:
CBT And Venlafaxine Treatments For Anxiety In Alcoholism
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批准号:7103374
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项目类别:
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资助金额:$49.69万
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财政年份:2003
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负责人:DOMENIC A CIRAULO
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依托单位:
ASSESSMENT OF IV COCAINE USING PHARMACOKINETIC/PHARMACODYNAMIC EFFECT
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批准号:6304498
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项目类别:
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资助金额:$4.27万
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财政年份:1999
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负责人:DOMENIC A CIRAULO
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依托单位:
SUBLINGUAL BUPRENORPHINE IN NONDEPENDENT OPIATE USERS
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批准号:6114459
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项目类别:
-
资助金额:$4.27万
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财政年份:1998
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负责人:DOMENIC A CIRAULO
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依托单位:
BOSTON UNIVERSITY CRU FOR ALCOHOLISM TREATMENT
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批准号:6168429
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项目类别:
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资助金额:$46.68万
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财政年份:1997
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负责人:DOMENIC A CIRAULO
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依托单位:
BOSTON UNIVERSITY CRU FOR ALCOHOLISM TREATMENT
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批准号:6533585
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项目类别:
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资助金额:$46.68万
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财政年份:1997
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负责人:DOMENIC A CIRAULO
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依托单位:
Boston University CRU for Alcoholism Treatment
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批准号:6686125
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项目类别:
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资助金额:$47.5万
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财政年份:1997
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负责人:DOMENIC A CIRAULO
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依托单位:
BOSTON UNIVERSITY CRU FOR ALCOHOLISM TREATMENT
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批准号:2769231
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项目类别:
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资助金额:$22.7万
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财政年份:1997
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负责人:DOMENIC A CIRAULO
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依托单位:
海外基金