GLYBURIDE VERSUS INSULIN IN THE MANAGEMENT OF GESTATIONAL DIABETES

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。这项研究的主要目的是评估格列本脲与胰岛素在治疗营养治疗无效的妊娠期糖尿病患者中的疗效。这些受试者是在加利福尼亚州洛杉矶的King Drew医学中心产科接受营养治疗无效的。这是一项前瞻性、随机、开放的试验。400名患有妊娠期糖尿病的孕妇将被招募参加这项研究，她们通过ADA饮食未能实现足够的血糖控制。这些女性将被随机分配到两组(A=接受胰岛素治疗的患者(200人)和B=接受格列本脲治疗的患者(200人))。所有民族的合格科目都将被录取。所有受试者都将在整个怀孕期间进行血糖监测，并将在出现

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The main purpose of this study is to assess the efficacy of glyburide compared to insulin in the management of gestational diabetic subjects that did not respond to nutritional therapy in the Obstetrics Department of King Drew Medical Center, Los Angeles, CA. This is a prospective, randomized and open trial. Four hundred pregnant women with gestational diabetes who have failed to achieve adequate blood glucose control on ADA diet will be recruited for the study. The women will be randomly assigned into the two Groups (A=Insulin recipients (200) and B=Glyburide recipients (200)). Eligible subjects from all ethnic groups will be enrolled. All subjects will be followed by blood glucose monitoring throughout pregnancy and adjustments of medication will be made when a