AMNIOTIC FLUID AND INFANT MONITORING FOR PARATHYROID HORMONE-RELATED PROTEIN

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。目的：探讨妊娠期羊水中甲状旁腺激素相关蛋白的含量变化。PTHrP由胎儿肺产生最初是广泛的。随着气囊的发育，PTHrP的产生变得限于气囊的衬里。在妊娠期间，发育中的肺产生胎儿肺液，分泌到羊水中。胎儿肺液的分泌途径遵循呼出的空气，通过鼻子和嘴进入羊膜腔。我们推测肺通过胎儿肺液向羊水提供PTHrP。此外，我们推测，PTHrP的浓度增加在妊娠期间类似于饱和磷脂酰胆碱和磷脂酰甘油。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. To determine the concentration of parathyroid hormone related protein in amniotic fluid during the course of gestation. The production of PTHrP by the fetal lung is at first widespread. As the air sacs develop the production of PTHrP becomes restricted to the lining of the air sacs. During gestation the developing lungs produce fetal lung fluid which is secreted into the amniotic fluid. The path of the secreted fetal lung fluid follows that of exhaled air, through the nose and mouth into the amniotic cavity. We hypothesize that the lung contributes PTHrP to the amniotic fluid via fetal lung fluid. Further, we hypothesize that the concentrations of PTHrP increase during gestation similar to saturated phosphatidylcholine and phosphatidylglycerol.