GENE POLYMORPHISMS AND INTERVENTIONS TO PREVENT DISABILITY IN COPD PATIENTS

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。在美国，慢性阻塞性肺病是导致死亡和残疾的主要原因。尽管肺功能没有改善，但运动已被证明可以提高COPD患者的身体功能。这些结果表明，是其他器官系统，而不是肺，对训练做出反应并导致改善。有证据表明，慢性阻塞性肺病患者的骨骼肌受到疾病的影响，而骨骼肌对运动训练有反应。最近的研究表明，COPD患者的这些肌肉异常可能与细胞因子水平升高有关。此外，细胞因子基因的变化已被证明可以调节炎症反应，并可能在残疾的进展中发挥作用。本研究的主要目的是确定两种不同的运动干预对COPD患者身体活动水平、身体功能、身体成分和细胞因子水平的影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Chronic obstructive pulmonary disease is a major cause of death and disability in the United States. Exercise has been shown to increase physical function in patients with COPD despite a lack of improvement in their lung function. These results suggest that it is other organ systems, and not the lungs, that respond to training and result in the improvements. There is evidence to suggest that the skeletal muscle of COPD patients is affected by the disease, and it is the skeletal muscle that responds to the exercise training. Recent research indicates that these muscular abnormalities in COPD patients may be associated with elevated cytokine level. Additionally, changes in the cytokine genes have been shown to modulate the inflammatory response and may play a role in the progression towards disability. The primary purpose of this investigation will be to determine the effect of two different exercise interventions on physical activity levels, physical function, body composition, and cytokine levels in patients with COPD.