THE EFFECT OF RISEDRONATE ON BONE TURNOVER AND BONE MASS IN OLDER MEN RECEIVING

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。这项建议将研究利塞膦酸盐对骨丢失高危男性人群的治疗干预。前列腺癌是美国男性最常见的癌症，也是癌症死亡的第二大原因。在过去的十年里，越来越多的男性正在接受激素抑制疗法治疗局部晚期疾病。最近的研究表明，黄体生成素释放激素(LHRH)激动剂的这种激素抑制会导致快速的骨丢失和增加骨质疏松性骨折的风险。老年男性髋部骨折和其他脆性骨折的发病率增加是一个重大的公共卫生问题。髋部骨折的成本很高，增加了死亡率，并严重损害了幸存者的独立性和生活质量。在局部晚期前列腺癌患者接受激素抑制治疗的男性中，可能会使这一问题复杂化，这是这项研究的基本原理。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This proposal will examine a therapeutic intervention with risedronate in a population of men at high risk for bone loss. Carcinoma of the prostate gland is the most commonly diagnosed cancer in U.S. men, and is the second leading cause of cancer death. Over the last decade, more and more men are being treated with hormonal suppression therapy for locally advanced disease. Recent studies have shown that such hormonal suppression with Luteinizing Hormone Releasing Hormone (LHRH) agonists leads to rapid bone loss and increased risk of osteoporotic fractures (1). The increased incidence of hip fractures and other fragility fractures in older men is a major public health issue. Hip fractures are costly, increase mortality and significantly compromise the independence and quality of life of the survivors. The potential for compounding this problem in men treated with hormonal suppression for locally advanced prostate carcinoma is the rationale for this study.