PROSPECTIVE EVALUATION OF ADULTS WITH THE ASEPTIC MENINGITIS SYNDROME

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。这项研究的目的是更好地确定哪些脑膜炎患者具有低风险的紧急可治疗原因，以说明他们的脑膜炎。这项研究的设计是为了收集关于患者经历的症状、PE的发现、所有实验室的结果以及医院病历中记录的任何健康问题的相关信息的详细信息。可利用的剩余脊髓液将用于检测肠道病毒。不会进行进一步的脊椎抽吸手术。将在基线和两周后抽取血液进行虫媒病毒检测。如果没有发现患者脑膜炎发作的原因，将进行其他血液测试，以检查其他可能的细菌或病毒。GCRC的后续访问将在基线、两周、四周和三个月进行。在这些访问中，将进行有关症状、神经检查和血液的问题。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to better identify which patients with meningitis are at low risk of having an urgent treatable cause accounting for their meningitis. The design of the study is to collect detailed information regarding the symptoms the patients have experienced, the findings on PE, the results of all labs, as well as pertinent information recorded in the hospital chart about any health problems. Available left over spinal fluid will be used to test for enteroviruses. No further spinal taps will be done. Blood will be drawn at baseline and at two weeks for testing for arboviruses. If no cause is found for the patient's episode of meningitis, other blood tests will be performed to check for other possible bacteria or viruses. Follow-up visits at the GCRC will be done at baseline, two weeks, four weeks and three months. At these visits, questions regarding symptoms, a neurological exam and blood will be done.