CPCRA 060: A PROSPECTIVE STUDY OF LONG-TERM CLINICAL, VIROLOGIC OUTCOMES IN HIV

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。本研究的目的是提供一种长期监测治疗或管理策略的机制。该研究的主要目的是比较随机分配到不同HIV治疗管理策略的参与者的发病率和死亡率。次要目标是：1)研究长期病毒学和免疫学变化与HIV疾病进展的关系；2)描述治疗方式随时间和自然历史的变化模式；3)管理策略事件比较；4)对出现临床事件的患者进行研究；5)比较人口统计和风险类别；6)确定基因型模式与临床疾病进展的关系。这项研究将招募约4000名患者，大约需要5年时间才能完成。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to provide a mechanism for long-term monitoring of treatment or management strategies. The primary objective of the study is to compare rates of morbidity and mortality in participants randomized to different HIV treatment management strategies. The secondary objectives are: 1) to study the association of long-term virologic and immunologic changes with progression of HIV disease; 2) describe patterns of change in treatment over time and natural history; 3) to compare incidents of management strategies; 4) conduct studies for those who develop clinical events; 5) compare demographics and risk categories; 6) to determine relationships between genotypic patterns and clinical disease progression. This study will enroll about 4,000 patients and will take approximately five years to complete.