PANCREATIC ISLET CELL FUNCTION AND GLUCOSE TOLERANCE FOLLOWING TRANSPLANT

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。胰腺切除术是治疗慢性胰腺炎相关疼痛综合征的一种方法。由于胰腺内分泌功能的丧失，导致严重的糖尿病。在手术时分离胰岛并将这些含有胰岛素的细胞送回胰岛，即胰岛自体移植，是一种减轻胰腺切除术相关糖尿病的实验手段。先前的研究已经证实，这种方法可以预防糖尿病，但不清楚自体胰岛移植后胰岛功能能维持多久。本研究旨在评估患者自体胰岛移植前后的胰岛素分泌和血糖控制能力。受试者在精氨酸输注后和口服葡萄糖耐量试验期间测量胰岛素分泌。这些测试在术后6、12、24和36个月重复，以确定胰岛移植物随时间的功能。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Pancreatectomy is one approach to treating the pain syndrome associated with chronic pancreatitis. This leads to severe diabetes because of loss of pancreatic endocrine function. Isolation of the pancreatic islets at the time of surgery and return of these insulin containing cells, islet autotransplantation, is an experimental means of mitigating the diabetes associated with pancreatectomy. Previous work has established that this approach can lead to good outcomes with prevention of diabetes but it is not clear how long islet function persists after autotransplant. This study is designed to evaluate patients before and serially after islet autotransplant to determine their ability to secrete insulin and control their blood glucose. Subjects have insulin secretion measured after an infusion of arginine and during an oral glucose tolerance test. These tests are repeated at 6, 12, 24 and 36 months after surgery to determine the function of the islet grafts over time.