EPIDEMIOLOGY OF BMI REBOUND

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。这项研究的目的是准确确定体重指数(BMI)反弹的儿童年龄，并评估从3岁开始的一组儿童BMI反弹时间的潜在相关性。更好地了解BMI反弹的流行病学可以在超重之前更好地识别未来肥胖的高危儿童。阐明体重指数反弹时间的决定因素可能会导致制定预防肥胖发展的策略。一个主要的目标是用双能X射线吸收法(DXA)评估体重指数的变化与身体成分变化的关系。我们将研究体重指数反弹的时间和体重指数反弹时的体脂百分比与性别、种族和社会经济地位的关系。我们将评估BMI反弹时间的潜在决定因素，包括饮食、体力活动和父母体重指数。我们将研究体重指数反弹的时间与7岁时体脂百分比、体脂分布、血压、血脂和脂蛋白浓度、空腹胰岛素、血糖和瘦素水平以及左心室重量的关系。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to precisely determine the age of children at Body Mass Index (BMI) rebound and evaluate potential correlates of the timing of BMI rebound in a cohort of children beginning at age 3 years. Better understanding of the epidemiology of BMI rebound could lead to improved identification of children at high risk of future obesity prior to excess weight gain. Elucidation of the determinants of the timing of BMI rebound could lead to the development of strategies to prevent the development of obesity. A major objective is to evaluate the relationship of changes in BMI with changes in body composition using dual energy x-ray absorptiometry (DXA). We will examine the association of the timing of BMI rebound and the percent body fat at the time of BMI rebound with gender, ethnic group, and socioeconomic status. We will evaluate the potential determinants of the timing of BMI rebound including diet, physical activity, and parental body mass index. We will examine the relationship of the timing of BMI rebound to percent body fat, distribution of body fat, blood pressure, plasma lipid and lipoprotein concentrations, fasting insulin, glucose and leptin levels and left ventricular mass at age 7 years.