VISCERAL ADIPOSITY AND CVD RISK IN WOMEN

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。肥胖已被确定为II型糖尿病和心血管疾病的危险因素。随着肥胖问题在美国的流行程度和严重程度的增加以及发病年龄的下降，人们对肥胖的关注也在增加。然而，用体重指数来衡量的肥胖的影响似乎因种族而异。体重指数每增加一个单位，与白人相比，黑人血压和甘油三酯的增加较少，高密度脂蛋白胆固醇的下降较少。对这一现象的解释尚不清楚。我们建议评估肥胖与心血管风险关系中的种族差异与脂肪分布差异有关的概念。我们将通过一项针对年轻成年黑人和白人女性的队列研究来做到这一点，这些女性此前曾作为NHLBI生长与健康研究的一部分被跟踪。在这项研究中，全身脂肪将通过双能x线吸收仪（DEXA）测定，腹部（或内脏）脂肪将通过磁共振成像（MRI）测量。我们还将利用在儿童和青少年时期收集的关于青春期成熟和饮食的信息来评估有效性

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Obesity has been well established as a risk factor for type II diabetes mellitus and cardiovascular disease. Concern about obesity has increased as the prevalence and severity of this problem in the United States has increased and the age at onset has decreased. However, the impact of obesity measured by body mass index appears to differ by race. For each unit increase in body mass index, blacks have less of an increase in blood pressure and triglycerides and less of a decrease in HDL cholesterol compared to whites. The explanation for this phenomenon remains unclear. We propose to evaluate the concept that these racial differences in the relationship of adiposity to cardiovascular risk are related to differences in the distribution of fat. We will do this through a cohort study of young adult black and white women who have been followed previously as part of the NHLBI Growth and Health Study. In this study, total body fat will be determined by dual energy x-ray absorptiometry (DEXA), and intra-abdominal (or visceral) fat will be measured by magnetic resonance imaging (MRI). We will also utilize information on pubertal maturation and diet collected on this cohort in childhood and adolescence to evaluate potent