VARIABILITY BETWEEN INDIVIDUALS WITH RESPECT TO COGNITIVE AND PHYSIOLOGICAL

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。情绪唤起及其认知后果的问题不仅对大脑有短期的，有时是不可逆的神经毒性影响。我们需要更好地理解压力的这些潜在影响，以最大限度地降低风险，并最终为已经发生的损害开发更好的治疗方法。这项研究构成了调查应激反应的短期和长期影响的关键第一步，使用跨学科的方法与最先进的技术相结合，以建立唤醒下人类表现和神经功能的急需规范。本研究的主要目的是：（a）检验个体之间在神经、心脏和内分泌应激反应测量方面的差异;（B）研究生理应激反应是否能准确预测个体对唤醒的认知弹性，这是通过对相关线索的预注意和注意利用以及对无关线索的筛选来衡量的;以及c）阐明补偿神经机制在那些最有效地改善觉醒的认知和生理效应的个体中的作用。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The problem of emotional arousal and its cognitive consequences not only has short-term,sometimes irreversible ,neuro-toxic effects on the brain. These potential effects of stress need to be better understood both to minimize risk,as well as eventually to develop better treatment for damage that has already occurred. This study constitutes a critical first step in investigating both short and long-term effects of stress reactivity, using an inter-disciplinary approach combined with state of the art technology, to establish much needed norms on human performance and neurological function under arousal. The primary aims of this study are to: a) examine variability between individuals on neural,cardiac,and endocrine measures of stress reactivity; b) to investigate whether,for each individual,physiological stress reactivity accurately predicts that individual's cognitive resilience to arousal,as measured by pre-attentive and attentive utilization of relevant cues and screening of irrelevant cues; and c) to elucidate the role of compensatory neural mechanisms in those individuals who are most efficient at ameliorating the cognitive and physiological effects of arousal.