NEUROCHEMICAL BASIS OF SLEEP DISORDERS IN NEURODEGENERATIVE DISEASES

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。我们正在研究伴随神经退行性疾病的睡眠障碍，包括神经退行性疾病多系统萎缩(MSA)、进行性核上性瘫痪(PSP)、帕金森病(PD)、阿尔茨海默病(AD)、路易体痴呆(DLB)、亨廷顿病(HD)、散发性橄榄脑桥小脑萎缩(OPCA)和特发性快速眼动(REM)睡眠行为障碍(RBD)。这些疾病与几种睡眠障碍有关，包括快速眼动(REM)睡眠行为障碍(RBD)以及阻塞性和中枢性睡眠呼吸暂停。本研究旨在研究RBD和OSA在这些神经系统疾病患者以及单纯RBD患者中的神经化学基础。我们将使用一种功能成像技术，正电子发射断层扫描(PET)，结合两种生化试剂(配体)来研究大脑中的神经递质密度。这些试剂包括[11C]二氢四苯并([11C]DTBZ)和[11C]甲基哌啶(C)4(C)丙酸甲酯([11C]PMP)。这些研究将帮助我们了解RBD和OSA的生化基础，这些信息将被用来指导我们尝试治疗这些症状。我们将研究190名被诊断为MSA、PSP、PD、AD、DLB和sOPCA、特发性RBD和正常对照的人。研究对象必须在45岁至75岁之间。我们对研究男性和女性都很感兴趣，也对研究来自所有民族和种族背景的人感兴趣。怀孕或哺乳婴儿的妇女不能参加这一项目。如果个人患有神经或精神疾病，可能会干扰这项研究，他们可能不会参与这一项目。如果他们有可能影响项目的疾病或以前的重大疾病，他们可能不会参加这个项目。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We are studying sleep disturbances accompanying the neurodegenerative diseases Multiple System Atrophy (MSA), Progressive Supranuclear Palsy (PSP), Parkinson's Disease (PD), Alzheimer's Disease (AD), Dementia with Lewy Bodies (DLB), Huntington's Disease (HD), Sporadic Olivopontocerebellar Atrophy (OPCA), and Idiopathic rapid eye movement (REM) sleep behavior disorder (RBD). These diseases are associated with several sleep disorders, including rapid eye movement (REM) sleep behavior disorder (RBD), and both obstructive and central sleep apnea. The present study is designed to investigate the neurochemical basis of RBD and OSA in patients with these neurological disorders, and in patients with RBD alone. We will use a functional imaging technique, positron emission tomography (PET), with two biochemical agents (ligands) to study neurotransmitter densities in the brain. The agents include [11C]dihydrotetrabenazine ([11C]DTBZ) and [11C]methylpiperidin(c)4(c)yl propitionate ([11C]PMP). These studies will help us understand the biochemical basis of RBD and OSA and this information will be used to inform our attempts at treatment for these symptoms. We will study 190 people who have been diagnosed with MSA, PSP, PD, AD, DLB, and sOPCA, Idiopathic RBD, and normal controls. Research subjects must be between the ages of 45 and 75. We are interested in studying both men and women, and in studying people from all ethnic and racial backgrounds. Women may not take part in this project if they are pregnant or breast-feeding a baby. Individuals may not take part in this project if they have a neurologic or psychiatric condition that might interfere with this study. They may not take part in this project if they have a medical illness or a prior significant illness that might affect the project.