FATTY ACID METABOLISM AND INSULIN SENSITIVITY: THE ROLE OF ENDURANCE EXERCISE

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。显然，饮食和运动的效果对肥胖者有益，但改善代谢健康的潜在机制尚不完全清楚。虽然越来越多的证据表明，在腹部肥胖的人脂质代谢的改变与一些医疗并发症，包括糖尿病，很少有人知道的因素负责这种影响。本申请中的项目旨在研究在减肥计划中添加耐力运动训练如何改变全身脂肪酸的可用性，摄取和氧化以及调节这些过程的细胞因子的表达。此外，我们将评估这些改变是否与胰岛素敏感性的改善有关。最后，这些实验将提供对脂肪酸代谢的细胞和全身适应的洞察，以响应可能导致胰岛素敏感性增强的减肥和运动训练。识别基因表达、全身脂肪酸代谢和临床结果测量（例如胰岛素敏感性）之间的关系可能导致肥胖症及其共病的治疗和/或预防方法的改进。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Clearly the effects of diet and exercise are beneficial for obese persons, but the underlying mechanisms for the improvements in metabolic health are not completely clear. Although mounting evidence suggests that alterations in lipid metabolism in persons with abdominal obesity are associated with a several medical complications, including diabetes, little is known about the factors responsible for this effect. The project in this application is designed to examine how the addition of endurance exercise training to a weight-loss program alters whole-body fatty acid availability, uptake, and oxidation as well as the expression of cellular factors that regulate these processes. In addition, we will evaluate whether these alterations are associated with improvements in insulin sensitivity. In the end, these experiments will provide insight into the cellular and whole-body adaptations in fatty acid metabolism in response to weight-loss and exercise training that may lead to enhancement of insulin sensitivity. Identifying relationships between gene expression, whole-body fatty acid metabolism and clinical outcome measurements, such as insulin sensitivity, may lead to improvements in the therapeutic and/or the preventative approach to obesity and its co-morbidities.