IDENTIFICATION OF BIOMARKERS FOR EARLY DIABETIC CARDIOMYOPATHY

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。心肌病是糖尿病的常见并发症，显著增加了患病个体的发病率和死亡率。这项提议将检验糖尿病心肌病与血脂异常直接相关的假设，血脂异常改变了非脂肪组织（如心脏）的脂质稳态。我们试图将早期糖尿病心脏结构和功能改变的灵敏的新超声心动图测量与血小板的脂质组学分析、骨骼肌中肌细胞内甘油三酯的质子磁共振波谱、视网膜脂质沉积、空腹血清甘油三酯和游离脂肪酸相关。我们的目标是开发新的生物标志物和实用的非侵入性方法，用于诊断糖尿病心肌病最早的结构和功能异常，并指导治疗，可应用于以人群为基础的实践。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Cardiomyopathy is a frequent complication of diabetes that contributes significantly to increased morbidity and mortality amongst affected individuals. This proposal will test the hypothesis that diabetic cardiomyopathy is directly related to dyslipidemia, which alters lipid homeostasis in non-adipose tissues such as the heart. We seek to correlate sensitive new echocardiographic measures of early diabetic alterations in cardiac structure and function with lipidomic profiling of platelets, proton magnetic resonance spectroscopy of intramyocellular triglyceride in skeletal muscle, retinal lipid deposits, and fasting serum triglycerides and free fatty acids. Our goal is to develop novel biomarkers and practical non-invasive methods for diagnosing the earliest structural and functional abnormalities in diabetic cardiomyopathy and for guiding therapy that may be applied to population-based practice.