RELAXATION AND HYPNOTIC TREATMENT OF DISABILITY-RELATED PAIN

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。本研究的目的是检查两种放松和暗示程序对疼痛和疼痛干扰的即时和长期影响，相对于彼此和无治疗基线（4或8周的长度，取决于患者的病情），在294名残疾人（最多134名脊髓损伤患者，160名飞行员）中：20名截肢患者，40名多发性硬化症患者，20名脑瘫患者，20名神经肌肉疾病患者，20名脊髓灰质炎后综合症患者，20名中风后疼痛患者，20名神经性疼痛患者)报告与残疾相关的疼痛。患有脊髓损伤的研究参与者将被随机分配到两种治疗条件之一：(1)“放松1”是一种放松训练条件，它将包括催眠的一些常见成分（专注于视觉线索，放松建议）以及感知镇痛的建议；(2)“放松2”是一种放松训练条件，它将只包括催眠的一个常见成分（专注于视觉线索）加上减少肌肉紧张的生物反馈。患有多发性硬化症的试点研究参与者将被随机分配到两种治疗条件中的一种：(1)上述放松1条件，或(2)传统的放松训练条件，包括渐进式肌肉放松。其余的试验参与者将被纳入上述放松1条件。主要结果变量（疼痛强度）和次要结果变量（疼痛干扰、医疗服务利用、抑郁和感知疼痛控制）均通过电话访谈进行评估。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to examine the immediate and long-term effects of two relaxation and suggestion procedures on pain and pain interference relative to each other and to a no-treatment baseline (four or eight weeks in length, depending on the patient's condition) in a group of 294 individuals with disability (up to 134 with spinal cord injury, and 160 pilots: 20 with amputation, 40 with multiple sclerosis, 20 with cerebral palsy, 20 with neuromuscular disease, 20 with post-polio syndrome, 20 post-stroke patients with pain, and 20 with neuropathic pain) who report bothersome disability-related pain. Study participants with SCI will be randomly assigned to one of two treatment conditions: (1) "Relaxation 1" which is a relaxation training condition that will include some components common to hypnosis (focusing on a visual cue, suggestions for relaxation) as well as suggestions for perceived analgesia or (2) "Relaxation 2" which is a relaxation training condition that will include only one component common to hypnosis (focusing on a visual cue) plus biofeedback for reduction of muscle tension. Pilot study participants with MS will be randomly assigned to one of two treatment conditions: (1) the Relaxation 1 condition described above, or (2) a traditional relaxation training condition that incorporates progressive muscle relaxation. The rest of the pilot participants will be enrolled in the Relaxation 1 condition described above. The primary outcome variable (pain intensity) and secondary outcome variables (pain interference, medical services utilization, depression, and perceived pain control) are all assessed via telephone interviews.