Hypnosis and Meditation for Pain Management in Veterans: Efficacy and Mechanisms

退伍军人疼痛管理的催眠和冥想：功效和机制

• 批准号: 8911781
• 负责人: Mark P Jensen
• 金额: $ 55.38万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-01 至 2019-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8911781
• 关键词: Address; Afghanistan; Aftercare; Biological; Brain; Characteristics; Clinical; Clinical Trials; Clinics and Hospitals; Complementary and alternative medicine; Country; Data; Development; Education; Educational process of instructing; Electroencephalography; Ensure; Expectancy; Family; Health; Health Services Accessibility; Healthcare; Hypnosis; Individual; Intervention; Iraq; Learning; Left; Life; Measurement; Measures; Mediator of activation protein; Meditation; Military Personnel; Modeling; Motivation; Neuropathy; Nociception; Outcome; Pain; Pain Research; Pain intensity; Pain management; Participant; Patients; Pattern; Play; Population; Post-Traumatic Stress Disorders; Public Health; Quality of life; Randomized; Randomized Clinical Trials; Randomized Controlled Trials; Relative (related person); Reporting; Request for Applications; Research; Role; Sampling; Self Management; Sleep; Sleep Disorders; Symptoms; Techniques; Testing; Therapeutic; Therapeutic Intervention; Time; Training; Translating; Treatment outcome; Veterans; Work; base; chronic pain; clinical practice; cognitive function; comparative efficacy; cost; effective therapy; efficacy testing; follow-up; improved; innovation; mindfulness; mindfulness meditation; psychologic; research to practice; response; secondary outcome; skills; social; treatment effect; trial comparing

DESCRIPTION (provided by applicant): Chronic pain is a significant problem for many Veterans, including new Veterans returning from Iraq and Afghanistan. It is also associated with a number of other significant problems, such as post-traumatic stress disorder and sleep problems. All of these can have significant negative effects of the quality of life of Veterans. Th current project seeks to help develop and evaluate two promising treatments that Veterans may find useful for helping them better manage chronic pain and its negative effects. Specifically, it s a randomized clinical trial comparing the efficacy of teaching skills in self-hypnosis and mindfulness meditation for reducing pain and improving the quality of life in Veterans. The project will also test hypotheses regarding how these treatment work by examining the meditating biological (e.g., brain activity measures), psychological (e.g., outcome expectancies), and social (e.g., therapeutic alliance) factors that could explain their effects. Potential moderators of treatment outcome (e.g., hypnotizability, baseline brain states) will also be examined. By better understanding the treatment effects of these interventions, as well as their mechanisms, and if the treatments are demonstrated to be effective as we anticipate they will be based on pilot and preliminary studies, Veterans will have more options for better managing chronic pain, and therefore maximizing the overall quality of their lives.

描述（由申请人提供）：慢性疼痛是许多退伍军人的一个重大问题，包括从伊拉克和阿富汗返回的新退伍军人。它还与许多其他重要问题有关，如创伤后应激障碍和睡眠问题。所有这些都可能对退伍军人的生活质量产生重大的负面影响。目前的项目旨在帮助开发和评估两种有前途的治疗方法，退伍军人可能会发现这对帮助他们更好地管理慢性疼痛及其负面影响有用。具体来说，这是一项随机临床试验，比较了自我催眠和正念冥想教学技能对减轻疼痛和提高退伍军人生活质量的功效。该项目还将通过检查冥想生物学（例如，脑活动测量），心理（例如，结果预期），和社会（例如，治疗联盟）的因素，可以解释他们的影响。治疗结果的潜在调节因素（例如，催眠能力，基线脑状态）也将被检查。通过更好地了解这些干预措施的治疗效果及其机制，如果治疗被证明是有效的，因为我们预计他们将基于试点和初步研究，退伍军人将有更多的选择来更好地管理慢性疼痛，从而最大限度地提高他们的整体生活质量。