EXERCISE TO IMPROVE HRV IN SUDDEN CARDIAC ARREST

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。本建议的目的是确定对接受自动植入式心脏复律除颤器(ICD)的心脏骤停(SCA)幸存者(N=10)进行运动干预的安全性和可行性。其次，建议测试运动对心脏自主神经功能(心率变异性(HRV))、健康结果(心率稳定性、一般健康相关生活质量、心理困扰)和主要不良心脏事件(心脏住院、急诊室就诊和心脏死亡率)的影响。主要结果是从基线到8周实施运动干预的安全性和可行性。我们感兴趣的是确定运动是否会影响心脏副交感神经系统的调节，并在室性心律失常、ICD休克和心脏死亡的复发中传递心脏保护作用。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this proposal is to determine the safety and feasibility of an exercise intervention in survivors (N=10) of sudden cardiac arrest (SCA) who have automatic implantable cardioverter defibrillators (ICDs). Secondarily, testing the impact of exercise on cardiac autonomic function (heart rate variability (HRV), health outcomes (heart rhythm stability, general health related quality of life, psychological distress), and major adverse cardiac events (cardiac hospitalizations, ER visits, and cardiac mortality) is proposed. The primary outcomes are safety and feasibility in implementing the exercise intervention from baseline to 8 weeks. Our interest is in determining if exercise will affect cardiac parasympathetic nervous system regulation and convey cardioprotective effects on recurrence of ventricular arrhythmias, ICD shocks, and cardiac mortality.