PREDICTION OF CARDIOMYOPATHY IN TYPE I DIABETES BY 31 P MRS

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。具体来说，我们将检验糖尿病患者表现出可逆的、运动诱导的PCr/ATP和PCr/无机磷酸盐下降的假设，这与能量供需失衡相一致。此外，我们建议这些改变只会出现在那些有系统性微血管疾病证据的糖尿病患者中，并且会伴随着电影MRI评估的收缩功能障碍的证据。最后，我们预计观察代谢和功能异常将预测短期和长期的结果。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Specifically we will test the hypothesis that patients with diabetes will exhibit reversible, exercise-induced decreases in PCr/ATP and PCr/inorganic phosphate consistent with an imbalance in energy supply and demand. Furthermore, we propose that these changes will be present only in those diabetic patients with evidence of systemic microvascular disease and will be accompanied by evidence of contractile dysfunction as assessed by cine MRI. Finally, we anticipate that the observation of metabolic and functional abnormalities will be predictive of short-and long-term outcomes.