ANTIDEPRESSANT EFFECTS ON EARLY LIFE STRESS

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。这项研究试图确定情绪治疗对没有或有儿童期身体或性虐待病史的重度抑郁症患者的影响。将通过三个主要方面来确定：1)哪种抗抑郁药在减少抑郁、担忧、愤怒或控制行为方面最有效；2)哪种抗抑郁药在使身体功能方面正常化方面更有效；以及3)上述身体功能的变化是否与情绪状态的改善同时发生。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study seeks to determine the effects of emotional treatment of people with major depression without and with a history of childhood physical or sexual abuse. Three major areas will be examined to determine the following: 1)which antidepressant is most effective in reducing feelings of depression, worry, anger or controlling behavior; 2) which antidepressant is more effective in normalizing aspects of physical function; and 3) whether changes in physical function mentioned above occur at the same time as improvement in emotional state.