ARTHRITIS SAMPLES

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。这项研究的目的是研究炎症刺激（可以激活人体自身免疫系统的东西）对健康人免疫细胞对其自身蛋白质的反应的影响。这些研究是关于自身免疫性疾病类风湿性关节炎研究项目的一部分。类风湿关节炎是一种自身免疫性疾病，在这种疾病中，免疫系统会对人体正常的关节蛋白（如软骨蛋白）产生破坏性反应。我们目前正在研究人类血细胞将这些关节蛋白转化为免疫系统可识别的形式的能力。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this research is to study the effect of inflammatory stimuli (things that can activate a person's own immune system) on the response of a healthy person's immune cells to that person's own proteins. These studies are part of a research project about the autoimmune disease Rheumatoid Arthritis. Rheumatoid Arthritis is an autoimmune disease in which the immune system makes a destructive response toward the body's normal joint proteins, such as cartilage proteins. We currently are studying the ability of human blood cells to convert these joint proteins into forms recognizable by the immune system.