NEURODEVELOPMENT EFFECTS OF ANTIEPILEPTIC DRUG STUDY (NEAD STUDY) (AMENDMENT #3R

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。这项研究的主要目的是根据妇女在宫内暴露后的神经行为发育情况，区分四种主要抗癫痫药物治疗癫痫的相对风险/益处。就个人和社会成本而言，这种认知和行为缺陷对人类的潜在后果是严重的。这项研究的结果将影响接受这些药物的妇女的临床管理，确定哪种主要的AED在神经行为发育方面是最安全的，从而改善她们孩子的健康。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The primary objective of this study is to differentiate the relative risks/benefit of four major AEDs in the treatment of women with epilepsy in terms of their children's neurobehavioral development after in utero exposure. The potential consequences of such cognitive and behavioral deficites in humans are severe in terms of both personal and societal costs. The results of the study will impact the clinical management of women receiving these medications, determine which of the major AEDs is safest in regard to neurobehavioral development and therefore improve the health of their children.