ASSESSMENT OF INDUCED SPUTUM TO EVAL ANTI-INFLAMMATORY AGENTS IN PTS W/CF

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。炎症在囊性纤维化(CF)肺部疾病的进展中起作用。皮质类固醇抗炎治疗在CF患者中已显示出临床益处，但不良反应限制了其应用。交替使用皮质类固醇和大剂量布洛芬治疗慢性阻塞性肺疾病的临床试验结果表明，抗炎治疗将减缓下降的速度。这项研究是一项双臂、多中心、随机、开放对照、平行分组试验，比较28天布洛芬或不治疗布洛芬对轻、中度慢性肺病患者诱导痰中炎症介质的影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Inflammatory contributes to the progression of cystic fibrosis (CF) lung disease. Anti-inflammatory therapy of corticosteroids in patients with CF have shown clinical benefit, but adverse effects have limited their use. Results from the clinical trials of alternate-day corticosteriods and high-dose ibuprofen in CF indicate anti-inflammatory therapy will slow the rate of decline. This study is a two arm, multicenter, randomized, open-label, controlled, parallel-group trial comparing the effects of 28 days of ibuprofen, or no treatment on inflammatory mediators in induced sputum in subjects with mild to moderate CF lung disease.