SERUM BILE ACID LEVEL IN PREGNANT WOMEN WITH AND WITHOUT HIV INFECTION

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。妊娠期间血清胆汁酸升高与产科胆汁淤积症(OC)有关，后者具有极大的胎儿死亡和其他并发症的风险。这些都是胆汁酸引起的血管胎盘功能不全的结果。OC在有潜在肝病(丙型肝炎感染)的患者中更为常见。感染艾滋病毒的妇女会受到可能增加OC风险的肝毒药物的影响。为了确定感染艾滋病毒的妇女在怀孕期间是否增加了血清胆汁酸水平，我们将比较40名感染艾滋病毒的妇女、10名丙型肝炎感染者和10名未感染的孕妇在怀孕第二和第三个月期间的血清胆汁酸水平以及脐带血中的胆汁酸水平。我们将确定血清胆汁酸水平与新生儿出生条件之间的关系。我们将通过比较继续接受治疗的艾滋病毒感染孕妇与其他受试者怀孕最后一个月和产后胆汁酸水平的下降来确定抗逆转录病毒药物是否影响胆汁酸水平。我们还将对UCHSC的OC进行回顾性研究，以确定与HIV感染孕妇的胆汁酸水平相关的临床和生化结果与正常妊娠OC的临床、生化和流行病学特征之间的潜在相似性。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Serum bile acid elevations during pregnancy are associated with obstetric cholestasis (OC), which carries significant risks of fetal demise and other complications. These are a consequence of bile acid-induced vascular placental insufficiency. OC is more common in patients with underlying liver disease (hepatitis C infection). HIV-infected women are subject to heptatotoxic agents that might increase the risk of OC. To determine if HIV-infected women have increased serum bile acid levels during pregnancy, we will compare serum bile acid levels during the 2nd and 3rd trimesters of pregnancy and in the cord blood of 40 HIV-infected, 10 Hep C-infected, and 10 uninfected pregnant women. We will identify associations between serum bile acid levels and birth conditions of the neonate. We will determine if antiretroviral medication affects bile acid levels by comparing the decrease between last month of pregnancy and post-partum in HIV-infected pregnant women who continue on therapy vs. other subjects. We will also conduct a retrospective study of OC at UCHSC to identify potential similarities between the clinical and biochemical findings associated with bile acid levels in HIV-infected pregnant women and the clinical, biochemical, and epidemiological characteristics of OC in normal pregnancy.