IMMUNOGENETICS OF POLYGLANDULAR FAILURE

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。整个方案分析了大量患有自身免疫的患者及其亲属的自身抗体的表达。该方案的临床研究中心部分允许对一小部分表达21-羟基酶自身抗体的个体进行代谢评估，以确定Addison病的存在规律，并前瞻性地确定向显性Addison病的进展，此外，还可以对表达抗胰岛自身抗体的个体进行葡萄糖和胰岛素分泌的评估，以诊断糖尿病并跟踪高危人群的进展。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The overall protocol analyzes expression of autoantibodies for a large number of patients and their relatives with autoimmunity. The clinical research center portion of the protocol allows the metabolic evaluation of a much smaller group of individuals expressing 21-hydroxylase autoantibodies to rule of the presence of Addison's disease and to prospectively define the progression to overt Addison's disease and in addition for individuals expressing anti-islet autoantibodies, glucose and insulin secretion is evaluated, to diagnose diabetes and to follow progression to diabetes in those at risk.