EARLY TREATMENT OF ALS WITH NUTRITION AND NIPPV

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。ALS是一种进行性疾病，无法治愈，治疗效果最低。临床经验表明，患者的体重减轻是由于肌肉质量的减少，但也是由于热量摄入的减少。假设：充足的营养可能对生存产生积极影响。一组措施可作为全球ALS进展的定量指标，但尚未开发类似的措施来评估营养状况。目的：根据前瞻性数据开发和验证方法，以确定能量平衡，该方法将适用于未来的营养和无创通气多中心III期研究。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. ALS is a progressive disease with no cure and minimally effect treatment. Clinical experience indicates that patients lose weight from loss of muscle mass, but also from reduced caloric intake. Hypothesis: Adequate nutrition may have a positive impact on survival. A group of measures are available as quantitative indices of global ALS progression, but similar measures have not been developed to evaluate nutritional status. Objective: Develop and validate methods from prospective data to determine energy balance that will be applicable in a future multicenter Phase III study of nutrition and non-invasive ventilation.