A RANDOMIZED TREATMENT TRIAL OF MILD GESTATIONAL DIABETES

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。为了确定轻度妊娠期糖尿病是否是不良围产儿结局的危险因素，以及在识别和治疗轻度疾病患者方面是否有效，建议对空腹血糖水平正常的患者进行随机临床试验。这项研究将对随机接受饮食治疗的患者和随机接受不治疗的患者进行比较。被随机分成不接受治疗的患者与另一组没有通过50克葡萄糖筛查测试但没有患有妊娠期糖尿病的患者没有什么区别。这将最大限度地减少产科或医疗干预的混杂影响。在试验中，与轻度妊娠期糖尿病患者的混淆变量匹配的非糖尿病对照组也将被纳入。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. To determine whether mild gestational diabetes is a risk factor for adverse perinatal outcome and whether there is utility in identifying and treating patients with mild disease, a randomized clinical trial is proposed of patients with a normal fasting glucose level. The study will compare patients who have been randomized to diet therapy with patients who have been randomized to no treatment. Patients who have been randomized to no treatment will be indistinguishable from another enrolled group of patients who have failed the 50-gram glucose screening test but who do not have gestational diabetes. This will minimize the confounding influence of obstetrical or medical interventions. A non-diabetic control group, matched for confounding variables with the mild gestational diabetic patients in the trial, will also be enrolled.