BINGE EATING: CLINICAL PATTERNS AND BIOLOGICAL CORRELATES

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。这项研究的目的是确定神经性暴食症暴饮暴食发作的规模是否与摄入测试餐后更高水平的冲动、更低水平的饱腹感和迟钝的CCK反应有关。先前的研究表明，与正常对照组相比，患有神经性暴食症的女性在食用试餐后的饱腹感较低，并释放较低水平的CCK。CCK是一种在肠道中产生的荷尔蒙，会引发饱腹感。因此，神经性暴食症的暴饮暴食发作可能部分是由于缺乏饱腹感信号造成的。然而，这些发现可能与神经性暴食症的其他特征有关，如通便或节制饮食。此外，最近的研究质疑了根据食物消耗量来定义暴饮期的有效性。这项研究将比较患有神经性贪食症的女性和客观上暴饮暴食的女性，被诊断为神经性贪食症的女性，除非她们在暴饮暴食时不消耗大量食物，而不进食障碍的女性作为对照。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to determine if the size of binge-eating episodes in bulimia nervosa is associated with greater levels of impulsiveness, lower levels of satiety, and blunted cholecystokinin (CCK) response following ingestion of a test meal. Previous research has suggested the women with bulimia nervosa compared to normal control women report lower levels of satiety following consumption of a test meal and release lower levels of CCK. CCK is a hormone produced in the intestines that triggers sensations of satiety. Thus binge episodes in bulimia nervosa may partially result from deficient satiety signals. However, these findings could be associated with other features of bulimia nervosa such as purging or dietary restraint. Additionally, recent research has challenged the validity of defining binge episodes according to the amount of food consumed. This study would compare women with bulimia nervosa with objectively large binge eating episodes, women who would be diagnosed with bulimia nervosa except that they do not consume large amounts of food when they binge, and non-eating disordered control females.