Binge Eating: Clinical Patterns & Biological Correlates

暴饮暴食：临床模式

• 批准号: 6539134
• 负责人: Pamela K. Keel
• 金额: $ 19.73万
• 依托单位: HARVARD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-04-01 至 2004-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6539134
• 关键词: behavioral /social science research tag; binge eating disorder; bulimia nervosa; cholecystokinin; clinical research; disease /disorder classification; female; human subject; impulsive behavior; interview; pathologic process; psychological tests; questionnaires; satiations; sign /symptom

The long term objectives of this study are to explore the utility of defining binge-eating episodes in bulimia nervosa by the amount of food consumed and to reveal factors that contribute to the development or maintenance of bulimic symptoms. An additional objective is to improve the recognition of an alternative symptom cluster that resembles bulimia nervosa-purging subtype, except that perceived binge episodes do not involve objectively large amounts of food. Recent research indicates that a substantial number of young women suffer from this alternative symptom cluster (subjective bulimia nervosa-SBN) suggesting that SBN represents a significant public health concern. One specific aim of this study is to test the hypothesis that, like women with DSM-IV bulimia nervosa, women with SBN demonstrate clinically significant levels of distress and impairment. A second aim is to demonstrate that SBN is distinct from DSM-IV bulimia nervosa and thus should not be combined with this syndrome within one diagnostic category. The study proposes to extend preliminary data suggesting that women with bulimia nervosa have higher levels of impulsiveness compared to women with SBN. In addition, this study proposes a novel examination of whether, compared to women with SBN, women with bulimia nervosa demonstrate lower levels of satiety and blunted cholecystokin (CCK) release following a rest meal. The study will include 30 women with DSM-IV bulimia nervosa-purging subtype, 30 women with SBNm and 30 non-eating disordered control females. Subjects will complete psychological assessments including structured clinical interviews and standardized questionnaire assessments of depression, anxiety, impulsiveness, and social and occupational functioning. Subjects will also participate in assessments of post-prandial satiety and CCK release. This study will test a model of bulimia nervosa in which deficient satiety signals fail to decrease the impulse to eat which, combined with poor impulse control, increases the liability to experience objectively large binge-eating episodes by the amount of food consumed and reveal etiologic or maintaining factors for objectively large bing episodes in bulimia nervosa. Further, this study has the potential to identify a new subtype of eating disorder that is worthy of study, treatment, and inclusion in nosological schemes.

本研究的长期目标是探讨神经性贪食症暴饮暴食发作的定义的食物消耗量的效用，并揭示因素，有助于发展或维持贪食症状。 另一个目的是提高对类似于神经性贪食症清除亚型的替代症状群的识别，除了感知的暴食发作不涉及客观的大量食物。 最近的研究表明，相当数量的年轻女性患有这种替代症状群（主观神经性贪食症-SBN），这表明SBN是一个重大的公共卫生问题。 本研究的一个具体目的是检验这一假设，即与DSM-IV神经性贪食症女性一样，SBN女性表现出临床显著的痛苦和损害水平。 第二个目的是证明SBN与DSM-IV神经性贪食症不同，因此不应在一个诊断类别中与该综合征合并。 该研究建议扩展初步数据，表明与SBN女性相比，患有神经性贪食症的女性具有更高水平的冲动。 此外，这项研究提出了一种新的检查，与SBN女性相比，神经性贪食症女性在休息餐后是否表现出较低的饱腹感和减弱的胆囊收缩素（CCK）释放。 该研究将包括30名患有DSM-IV神经性贪食症清除亚型的女性，30名患有SBNm的女性和30名非进食障碍对照女性。受试者将完成心理评估，包括结构化临床访谈和抑郁、焦虑、冲动以及社会和职业功能的标准化问卷评估。 受试者还将参与餐后饱腹感和CCK释放的评估。 本研究将测试一种神经性贪食症模型，其中饱腹感信号不足无法降低进食冲动，结合不良的冲动控制，增加了客观上经历大量暴饮暴食事件的可能性，并揭示了神经性贪食症客观上大量暴饮暴食事件的病因或维持因素。 此外，这项研究有可能确定一种新的进食障碍亚型，值得研究，治疗和纳入疾病分类方案。