AMITRIPTYLINE TO TREAT PAINFUL BLADDER SYNDROME

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。间质性膀胱炎是一种慢性、疼痛的膀胱壁炎症状态，亨纳博士于1914年首次对其进行了特征描述。自20世纪80年代中期以来，NIDDK/NIH、间质性膀胱炎协会和非专业媒体的努力使这种疾病从默默无闻变成了显赫的地位，花费了数以亿计的联邦和私人资金来寻找治疗方法。尽管作出了这些努力，但对这种疾病的了解仍然很少，特征也很差，治疗大多是经验性的，不令人满意。根据国际大陆协会的定义，痛性膀胱综合征(PBS)是“与膀胱充盈有关的耻骨上疼痛的主诉，并伴有其他症状，如白天和夜间频率增加，在没有得到证实的尿路感染或其他明显病理的情况下。”虽然与间质性膀胱炎(IC)重叠，但PBS是基于患者症状对疾病的临床描述，而不依赖于尿动力学或膀胱镜检查结果。这项方案将比较口服阿米替林在“新诊断”、“治疗不成熟”的PBS患者和匹配的安慰剂中的有效性、安全性和耐受性，这些患者都接受了标准的教育/行为矫正计划。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Interstital cystitis is a chronic, painful inflammatory condition of the bladder wall first characterized in 1914 by Dr. Hunner. Efforts by the NIDDK/NIH, the Interstitial Cystitis Association and the lay press since the mid-1980's brought the disorder from obscurity to prominence with hundreds of millions of federal and private dollars spent in search for a cure. Despite these efforts, the disease is still poorly understood, poorly characterized, and treatment is mostly empirical and unsatisfactory. Painful bladder syndrome (PBS), as defined by the International Continence Society, is "the complaint of suprapubic pain related to bladder filling, accompanied by other symptoms, such as increased day-time and night-time frequency, in the absence of proven urinary infection or other obvious pathology." Although overlapping with interstitial cystitis (IC), PBS is a clinical description of disease based on the patient's symptoms, and does not depend on urodynamic or cystoscopic findings. This protocol will compare the efficacy, safety and tolerability of oral amitriptyline in "newly diagnosed", "treatment naive" PBS patients with matching placebo, all receiving a standard education/behavioral modification program.